Ready. Set. Travel!

Kerry Manley is beating the rush. She is heading home to Denver for Thanksgiving, ahead of the estimated 25 million people who will be flying in a 12-day period.

"I don't like traveling with, like, ten million people," Manley tells CBS News correspondent Michelle Miller. "It's much easier when you do it earlier."

Along with the crush of the crowds, tougher restrictions at airports from the Transportation Security Administration will mean longer lines and delays.

"We expect the air traffic to be extremely heavy and we just don't know how the checkpoints are going to go," says David Stempler of the Air Travelers Association. "We hope it goes well, but plan for the worst, hope for the best."

Travelers should be prepared for the new rules about toiletries. Big bottles of liquids and gels in carry-ons won't fly anymore, reports Miller. So remember the 3-1-1 rule: three ounce containers of shampoos and lotions in the new, must-have tote — one, one-quart sized, zip-top baggie.

Dozens of airports are handing out baggies but, to be safe, pack one in advance or you could find yourself scrambling — or dumping — as you're rushing to the gate.

And always remember the golden rule: get to the airport early – two hours before your flight.

"People need to get the airport as soon as possible because the check-in lines, the security checkpoint lines and even the lines at the gate are going to be very long," warns Stempler.

All those hassles may drive you to the train, but you might have to fight for a seat. Amtrak expects to carry 125,000 passengers a day this week — 30 percent more than usual.

If you're flying, there is some good news. You could save money, even if you've already purchased your ticket.

"There are some specials this holiday season, and you can get that special fare," says Tom Parsons of Bestfares.com. "The airline might actually give you a voucher for a future flight."

Travelers will need patience. Flight delays are up this year. And to make matters worse, more bags are getting lost or mishandled, nearly double the number that went missing a year ago.